28 Optimised ART and alloBMT to reduce HIV reservoirs
نویسندگان
چکیده
منابع مشابه
How to best measure HIV reservoirs?
PURPOSE OF REVIEW The persistence of HIV within infected CD4 T cells is a major obstacle to eradication, and assessment of the strategies to reduce HIV reservoirs is one of the major challenges. Measuring HIV reservoirs accurately will be necessary to assess those strategies. The objective of this review is to present the most recent studies that may help to define the best markers to measure H...
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During anti-retroviral therapy (ART) HIV-1 persists in cellular reservoirs, mostly represented by CD4+ memory T cells. Several approaches are currently being undertaken to develop a cure for HIV-1 infection through elimination (or reduction) of these reservoirs. Few studies have so far been conducted to assess the possibility of reducing the size of HIV-1 reservoirs through vaccination in virol...
متن کاملHIV Persistence and Viral Reservoirs
Although antiretroviral therapy (ART) can effectively inhibit replication of human immunodeficiency virus type 1 (HIV-1), the virus is able to persist in cellular and anatomical viral reservoirs. Latently infected resting memory CD4 T-cells are an important cellular reservoir, and the central nervous system (CNS) an important anatomical reservoir for HIV-1 infection. The overall aim of this the...
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The stable latent reservoir for HIV-1 in resting memory CD4 T cells is a major barrier to curing HIV-1/AIDS. Studies on HIV-1 latency focused on regulation and reactivation of viral gene expression in the cells in which viral latent infection is already established. However, it is not well understood how virus becomes latent. In this study, we found that in a subset of memory precursor CD4 T ce...
متن کاملHIV reservoirs: pathogenesis and obstacles to viral eradication and cure.
Plasma HIV viremia can be suppressed and maintained below the limits of detection for prolonged periods of time in the vast majority of HIV-infected individuals who receive antiretroviral therapy (ART). Thus, the clinical outcome for HIV-infected individuals who have access to these drugs is dramatically improved. However, ART alone cannot eradicate HIV in infected individuals and this impedime...
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ژورنال
عنوان ژورنال: Journal of Virus Eradication
سال: 2017
ISSN: 2055-6640
DOI: 10.1016/s2055-6640(20)30733-0